Central Neuromedin U ( NMU ) Signaling in Body Weight and Energy Balance 1 Regulation : Evidence from NMU Receptor 2 Deletion and Chronic Central NMU 2 Treatment in Mice

Central Neuromedin U (NMU) Signaling in Body Weight and Energy Balance 1 Regulation: Evidence from NMU Receptor 2 Deletion and Chronic Central NMU 2 Treatment in Mice. 3 4 Emil Egecioglu, Karolina Ploj, Xiufeng Xu, Mikael Bjursell, Nicolas Salomé, Niklas 5 Andersson, Claes Ohlsson, Magdalena Taube, Caroline Hansson, Mohammad Bohlooly6 Y, David GA Morgan, Suzanne L Dickson 7 8 Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The 9 Sahlgrenska Academy at the University of Gothenburg, SE-405 30 Gothenburg, Sweden, 10 AstraZeneca R&D Mölndal, Sweden. 11 Department of Internal Medicine, The Sahlgrenska Academy at the University of 12 Gothenburg, Gothenburg, Sweden 13 14 Corresponding author: 15 Emil Egecioglu, PhD 16 Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, 17 The Sahlgrenska Academy at the University of Gothenburg, 18 Medicinaregatan 11, 19 PO Box 434, 20 SE-405 30 Gothenburg, 21 Sweden 22 Tel: +46 31 786 3876 23 Fax: +46 31 786 3512 24 Email: [email protected] 25 26 Disclosure summery: 27 E.E., N.S., N.A., C.O., M.T., C.H. and S.L.D. have nothing to declare. K.P, X.X., M.B., 28 M.B.Y. and D.G.A.M, are employed by AstraZeneca. 29 30 Running title: Anti-obesity actions of NMU. 31 32